Supplement Recommendations & Cautions for GLP-1 Users

Recommended Supplements

Due to reduced appetite and food intake, individuals on GLP-1 medications may benefit from targeted supplementation. Below are key supplements with clinical support:

  • Multivitamin with Iron: Covers general micronutrient gaps. Choose one with B12, D3, and iron.
  • Vitamin B12: Sublingual, oral, or intramuscular options. Especially important for vegetarians or those with fatigue or neurological symptoms.
  • Vitamin D3: Often dosed at 1,000–2,000 IU/day. Check serum levels before supplementing long-term.
  • Iron: 18–30 mg elemental iron, taken separately from calcium for best absorption. Use if menstruating or low ferritin.
  • Calcium Citrate: 500–600 mg doses, ideally twice daily. Supports bones and absorption is less dependent on stomach acid.
  • Magnesium: 250–400 mg/day to support muscles, digestion, and bowel regularity.
  • Protein Powder: Whey, soy, or plant-based options help meet protein targets when food intake is low.
  • Fiber Supplement: Psyllium husk or inulin for digestive health and satiety support.

Supplements to Use with Caution

  • Fat Blockers (e.g., orlistat): May reduce absorption of fat-soluble vitamins and cause GI issues.
  • Stimulants: Caffeine-based fat burners may increase nausea or interact with GLP-1 drugs.
  • Unregulated weight loss products: Avoid supplements with proprietary blends or ingredients not backed by clinical data.
  • Calcium carbonate: Less bioavailable than calcium citrate and can cause constipation.
  • High-dose iron: Can cause nausea or interfere with other minerals if not medically indicated.

Personalized Supplementation Tips

  • Base supplement needs on lab results when possible (e.g., ferritin, B12, 25-OH vitamin D).
  • Split doses of calcium and magnesium to improve tolerance and absorption.
  • Consider chewable or liquid formats if large pills cause nausea.
  • Consult a registered dietitian or medical provider to create a tailored regimen.

References

  1. NIH Office of Dietary Supplements. “Guidelines for Supplement Use.” Updated 2023.
  2. American Society for Metabolic and Bariatric Surgery. “Nutrient Recommendations for Low-Calorie Diets.” 2024.
  3. Endocrine Society. “Micronutrient Monitoring with GLP-1 Medications.” 2023.
  4. Mechanick JI et al. “Nutritional Considerations in Medical Weight Loss.” Obesity. 2022.