This guide outlines approved dosing schedules, titration protocols, and administration guidance for commonly prescribed GLP-1 receptor agonist medications. These protocols are based on manufacturer labels, clinical guidelines, and expert consensus.
Semaglutide (Ozempic®, Wegovy®, Rybelsus®)
- Ozempic (weekly injection):
- Start: 0.25 mg once weekly for 4 weeks
- Increase to 0.5 mg weekly; may increase to 1.0 mg or 2.0 mg if needed
- Max: 2.0 mg/week (T2D); 2.4 mg/week (obesity with Wegovy)
- Wegovy (weekly injection):
- Titration: 0.25 mg → 0.5 mg → 1.0 mg → 1.7 mg → 2.4 mg over 16–20 weeks
- Rybelsus (oral tablet):
- Start: 3 mg once daily for 30 days
- Then 7 mg daily; may increase to 14 mg after 30 days
Tirzepatide (Zepbound™, Mounjaro®)
- Start: 2.5 mg once weekly for 4 weeks
- Increase: 5 mg → 7.5 mg → 10 mg → 12.5 mg → 15 mg (every 4 weeks as tolerated)
- Max: 15 mg weekly
Liraglutide (Saxenda®, Victoza®)
- Saxenda (obesity):
- Titration: 0.6 mg → 1.2 mg → 1.8 mg → 2.4 mg → 3.0 mg (increase weekly)
- Victoza (T2D):
- Start: 0.6 mg daily for 1 week
- Then 1.2 mg or 1.8 mg daily
Dulaglutide (Trulicity®)
- Start: 0.75 mg or 1.5 mg once weekly
- May increase to 3.0 mg or 4.5 mg based on response and tolerance
General Administration Tips
- Inject subcutaneously into the abdomen, thigh, or upper arm
- Rotate injection sites to prevent irritation
- Take oral semaglutide (Rybelsus) on an empty stomach with no more than 4 oz of water; wait at least 30 minutes before eating
- If a dose is missed, follow medication-specific instructions for catch-up
Patient Counseling Tips
- Explain expected GI symptoms and titration timelines
- Review injection technique and safe disposal of pens/needles
- Encourage consistent timing (same day each week for weekly drugs)
Disclaimer
This content is intended for licensed healthcare professionals. Refer to official product labeling and institutional protocols for prescribing decisions.